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CBX3 / HP1 Gamma Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - CBX3 / HP1 Gamma Antibody (Internal) ALS12246
    Anti-CBX3 antibody IHC of human placenta.
    detail
  • WB - CBX3 / HP1 Gamma Antibody (Internal) ALS12246
    (0.3 ug/ml) Staining of A431 lysate (35 ug protein in RIPA buffer).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13185
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 21kDa
Dilution ELISA (1:32000), IHC-P (2.5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 11335
Other Names Chromobox protein homolog 3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein, CBX3
Target/Specificity Human CBX3. No cross-reactivity expected with HP1-alpha and HP1-beta. NP_009207.2 and NP_057671.2 represent same protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCBX3 / HP1 Gamma Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX3
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
Cellular Location Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
Citations (0)
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Background

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

References

Ye Q.,et al.J. Biol. Chem. 271:14653-14656(1996).
Ye Q.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Koike N.,et al.FEBS Lett. 467:17-21(2000).
Chen J.H.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.

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Discontinued
Cat# ALS12246
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