|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (2.5 µg/ml), WB (1:128000)|
|Other Names||N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase, 3.2.2.-, DNA-(apurinic or apyrimidinic site) lyase, AP lyase, 220.127.116.11, OGG1, MMH, MUTM, OGH1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||OGG1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MMH, MUTM, OGH1|
|Function||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells Isoform 2A: Mitochondrion.|
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Provided below are standard protocols that you may find useful for product applications.
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.
Aburatani H.,et al.Cancer Res. 57:2151-2156(1997).
Rosenquist T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
Roldan-Arjona T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
Radicella J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
Lu R.,et al.Curr. Biol. 7:397-407(1997).
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