|Application ||WB, IHC-P, E|
|Calculated MW||47315 Da|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Casein kinase I isoform epsilon, CKI-epsilon, CKIe, 220.127.116.11, CSNK1E|
|Target/Specificity||Human CSNK1E. Both reported variants represent identical protein (NP_001885.1 and NP_689407.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CSNK1E / CK1 Epsilon Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes|
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