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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD34 Antibody (clone MEC14.7)   

CD34 Antibody (clone MEC14.7)

Rat Monoclonal Antibody

     
  • IHC - CD34 Antibody (clone MEC14.7) ALS12262
    Anti-CD34 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IP, Flo
Primary Accession P28906
Reactivity Human, Mouse
Host Rat
Clonality Monoclonal
Clone Names MEC14.7
Calculated MW 41kDa
Dilution Flo (1:25-1:50), IHC-P (10 µg/ml), IP (2-10 µg/ml)
Additional Information
Gene ID 947
Other Names Hematopoietic progenitor cell antigen CD34, CD34, CD34
Target/Specificity Recognizes the mouse CD34 cell surface glycoprotein. mouse CD34 is expressed by hematopoietic progenitor cells in the bone marrow and also by endothelial cells.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCD34 Antibody (clone MEC14.7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD34
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues
Research Areas
Citations (0)

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Background

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

References

Simmons D.L.,et al.J. Immunol. 148:267-271(1992).
Satterthwaite A.B.,et al.Genomics 12:788-794(1992).
Nakamura Y.,et al.Exp. Hematol. 21:236-242(1993).
Freund D.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS12262
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