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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   B2M / Beta 2 Microglobulin Antibody   

B2M / Beta 2 Microglobulin Antibody

Mouse Monoclonal Antibody

     
  • IHC - B2M / Beta 2 Microglobulin Antibody ALS12263
    Anti-B2M antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP, Flo
Primary Accession P61769
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW 14kDa
Dilution Flo (1 µg/ml), IHC-P (10 µg/ml), WB (2-4 µg/ml)
Additional Information
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M
Target/Specificity Recognizes human b2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as soluble human b2-microglobulin. Does not cross-react with mouse, bovine, rabbit, dog or chicken b2-microglobulin.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsB2M / Beta 2 Microglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations (0)

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Background

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

References

Guessow D.,et al.J. Immunol. 139:3132-3138(1987).
He X.H.,et al.Sheng Wu Gong Cheng Xue Bao 20:99-103(2004).
Matsumoto K.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Tan J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12263
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