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TFEC Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - TFEC Antibody (Internal) ALS12274
    Anti-TFEC antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O14948
Reactivity Human, Mouse
Host Goat
Clonality Polyclonal
Calculated MW 39kDa
Dilution ELISA (1:32000), IHC-P (5 µg/ml),
Additional Information
Gene ID 22797
Other Names Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL
Target/Specificity Mouse TFEC.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTFEC Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFEC
Synonyms BHLHE34, TCFEC, TFECL
Function Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11467950}
Tissue Location Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.
Citations (0)

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Background

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.

References

Yasumoto K.,et al.Biochim. Biophys. Acta 1353:23-31(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12274
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