|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T-cell immunoglobulin mucin receptor 1, TIM, TIM-1, T-cell membrane protein 1, HAVCR1, KIM1, TIM1, TIMD1|
|Target/Specificity||16 amino acid peptide from near the center of human TIM-1.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||HAVCR1 / KIM-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIM1, TIM1, TIMD1|
|Function||May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.
Feigelstock D.,et al.J. Virol. 72:6621-6628(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Tami C.,et al.J. Virol. 81:3437-3446(2007).
van Timmeren M.M.,et al.J. Pathol. 212:209-217(2007).
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