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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CCR6 Antibody (aa18-46)   

CCR6 Antibody (aa18-46)

Goat Polyclonal Antibody

     
  • IHC - CCR6 Antibody (aa18-46) ALS12281
    Anti-CCR6 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC, E, Flo
Primary Accession P51684
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 42kDa
Dilution ELISA (1:75000), Flo (1-3 µg/10E6 cells), ICC (1:300), IHC-P (5 µg/ml) ,
Additional Information
Gene ID 1235
Other Names C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, Chemokine receptor-like 3, CKR-L3, DRY6, G-protein coupled receptor 29, GPR-CY4, GPRCY4, LARC receptor, CD196, CCR6, CKRL3, CMKBR6, GPR29, STRL22
Target/Specificity Recognizes human CCR6. Peptide sequence is <50% identical to other human chemokine receptors in this region. Species cross-reactivity: mouse.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCCR6 Antibody (aa18-46) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR6
Synonyms CKRL3, CMKBR6, GPR29, STRL22
Function Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell surface
Tissue Location Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes
Research Areas
Citations (0)

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Background

Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

References

Baba M.,et al.J. Biol. Chem. 272:14893-14898(1997).
Lautens L.L.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
Zaballos A.,et al.Biochem. Biophys. Res. Commun. 227:846-853(1996).
McCoy R.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Liao F.,et al.Genomics 40:175-180(1997).

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$ 395.00
Cat# ALS12281
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