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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TAOK3 / JIK Antibody (Internal)   

TAOK3 / JIK Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - TAOK3 / JIK Antibody (Internal) ALS12286
    Antibody (0.1 ug/ml) staining of human liver lysate (35 ug protein in RIPA buffer).
  • IHC - TAOK3 / JIK Antibody (Internal) ALS12286
    Anti-TAOK3 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H2K8
Reactivity Human, Rabbit, Pig, Horse, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 105kDa
Dilution ELISA (1:32000), IHC-P (2-3 µg/ml), WB (1:32000)
Additional Information
Gene ID 51347
Other Names Serine/threonine-protein kinase TAO3, 2.7.11.1, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18
Target/Specificity Human TAOK3.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTAOK3 / JIK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAOK3
Synonyms DPK, JIK, KDS, MAP3K18
Function Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane
Tissue Location Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver
Research Areas
Citations (0)

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Background

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

References

Tassi E.,et al.J. Biol. Chem. 274:33287-33295(1999).
Zhang W.,et al.Biochem. Biophys. Res. Commun. 274:872-879(2000).
Yustein J.T.,et al.Oncogene 22:6129-6141(2003).
Carter T.G.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12286
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