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TAOK3 / JIK Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H2K8 |
| Reactivity | Human, Rabbit, Pig, Horse, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 105kDa |
| Dilution | ELISA (1:32000), IHC-P (2-3 µg/ml), WB (1:32000) |
| Gene ID | 51347 |
|---|---|
| Other Names | Serine/threonine-protein kinase TAO3, 2.7.11.1, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18 |
| Target/Specificity | Human TAOK3. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | TAOK3 / JIK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAOK3 |
|---|---|
| Synonyms | DPK, JIK, KDS, MAP3K18 |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane |
| Tissue Location | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
References
Tassi E.,et al.J. Biol. Chem. 274:33287-33295(1999).
Zhang W.,et al.Biochem. Biophys. Res. Commun. 274:872-879(2000).
Yustein J.T.,et al.Oncogene 22:6129-6141(2003).
Carter T.G.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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