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MCM5 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - MCM5 Antibody ALS12296
    Anti-MCM5 antibody IHC of human colon.
  • WB - MCM5 Antibody ALS12296
    Jurkat cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose and...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P33992
Reactivity Human, Mouse, Monkey, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 82kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 4174
Other Names DNA replication licensing factor MCM5, 3.6.4.12, CDC46 homolog, P1-CDC46, MCM5, CDC46
Target/Specificity Peptide-KLH (KEVADEVTRPRPSGE).
PrecautionsMCM5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM5
Synonyms CDC46
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.
Cellular Location Nucleus.
Citations (0)

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Background

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

References

Hu B.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Goehring F.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Mimura S.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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$ 395.00
Cat# ALS12296
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