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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   BAX Antibody (clone 6A7)   

BAX Antibody (clone 6A7)

Mouse Monoclonal Antibody

     
  • WB - BAX Antibody (clone 6A7) ALS12297
    Extracts from Hela cell lysate was immunoprecipitated with clone 6A7 (lane 1), 4 ug purified...
  • IHC - BAX Antibody (clone 6A7) ALS12297
    Anti-BAX antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q07812
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 6A7
Calculated MW 21kDa
Dilution IHC-P (10-12 µg/ml)
Additional Information
Gene ID 581
Other Names Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4
Target/Specificity Amino acid:12-24 common to human, mouse, and rat Bax protein.
Reconstitution & Storage +4°C. Store undiluted.
PrecautionsBAX Antibody (clone 6A7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAX
Synonyms BCL2L4
Function Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Cellular Location Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane Isoform Gamma: Cytoplasm.
Tissue Location Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Research Areas
Citations (0)

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Background

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

References

Oltvai Z.N.,et al.Cell 74:609-619(1993).
Apte S.S.,et al.Genomics 26:592-594(1995).
Shi B.,et al.Biochem. Biophys. Res. Commun. 254:779-785(1999).
Schmitt E.,et al.Biochem. Biophys. Res. Commun. 270:868-879(2000).
Cartron P.F.,et al.Hum. Mol. Genet. 11:675-687(2002).

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$ 395.00
Cat# ALS12297
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