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CTSK / Cathepsin K Antibody

Rabbit Polyclonal Antibody

     
  • WB - CTSK / Cathepsin K Antibody ALS12298
    Western blot of Cathepsin K antibody ALS12298 with rat kidney lysates.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P43235
Reactivity Human, Mouse, Rat, Rabbit, Pig, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Dilution IHC-P (2.5 µg/ml), WB (0.5-4 µg/ml),
Additional Information
Gene ID 1513
Other Names Cathepsin K, 3.4.22.38, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Target/Specificity The antibody detects proform (43 kD) and the mature form (29 kD) of cathepsin K.
Reconstitution & Storage Long term: -70°C; Short term: -20°C
PrecautionsCTSK / Cathepsin K Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTSK
Synonyms CTSO, CTSO2
Function Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Cellular Location Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells
Tissue Location Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).
Research Areas
Citations (0)
citation

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Background

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

References

Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 544.50
Cat# ALS12298
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