|Application ||WB, IHC-P, IP|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Chicken|
|Dilution||IHC-P (2.5 µg/ml), WB (0.5-4 µg/ml),|
|Other Names||Cathepsin K, 188.8.131.52, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2|
|Target/Specificity||The antibody detects proform (43 kD) and the mature form (29 kD) of cathepsin K.|
|Reconstitution & Storage||Long term: -70°C; Short term: -20°C|
|Precautions||CTSK / Cathepsin K Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.|
|Tissue Location||Predominantly expressed in osteoclasts (bones)|
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Provided below are standard protocols that you may find useful for product applications.
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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