Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CR1 / CD35 Antibody (clone E11, Azide-free)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-Fr, Flo |
|---|---|
| Primary Accession | P17927 |
| Reactivity | Human, Baboon |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | E11 |
| Calculated MW | 224kDa |
| Dilution | Flo (1:50-1:100), IHC-P (10 µg/ml), |
| Gene ID | 1378 |
|---|---|
| Other Names | Complement receptor type 1, C3b/C4b receptor, CD35, CR1, C3BR |
| Target/Specificity | Is a single chain cell surface glycoprotein which exists in four allotypic forms (A, B, C, D) of 190kD, 220kD, 160kD and 250kD respectively. The molecule is expressed by granulocytes, monocytes, B cells and some T cells. Functionally CD35 acts as a r ... |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | CR1 / CD35 Antibody (clone E11, Azide-free) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CR1 |
|---|---|
| Synonyms | C3BR |
| Function | Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). |
| Cellular Location | Membrane; Single- pass type I membrane protein |
| Tissue Location | Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Mediates cellular binding of particles and immune complexes that have activated complement.
References
Klickstein L.B.,et al.J. Exp. Med. 168:1699-1717(1988).
Vik D.P.,et al.J. Immunol. 151:6214-6224(1993).
Gregory S.G.,et al.Nature 441:315-321(2006).
Wong W.W.,et al.J. Exp. Med. 169:847-863(1989).
Hourcade D.,et al.J. Exp. Med. 168:1255-1270(1988).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
