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F2 / Prothrombin / Thrombin Antibody

Mouse Monoclonal Antibody

     
  • IHC - F2 / Prothrombin / Thrombin Antibody ALS12319
    Anti-F2 / Thrombin antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P00734
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW 70kDa
Dilution ELISA (5-10 µg/ml), IHC-P (5 µg/ml), WB (10 µg/ml)
Additional Information
Gene ID 2147
Other Names Prothrombin, 3.4.21.5, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2
Target/Specificity Recognizes human Prothrombin, prethrombin-1, fragment 2, meizothrombin. Inhibits clotting and prothrombin activation.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsF2 / Prothrombin / Thrombin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F2
Function Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Cellular Location Secreted, extracellular space.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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Background

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

References

Degen S.J.F.,et al.Biochemistry 26:6165-6177(1987).
Wang W.,et al.Haemophilia 10:94-97(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Degen S.J.F.,et al.Biochemistry 22:2087-2097(1983).

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Discontinued
Cat# ALS12319
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