|Application ||IHC-P, IP, IHC-Fr, Flo|
|Dilution||Flo (20 µg/ml), IHC-Fr (1-10 µg/ml), IHC-P (10 µg/ml)|
|Other Names||Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5|
|Target/Specificity||Recognizes human CD40 cell surface antigen, a 48kD glycoprotein expressed by B lymphocytes and weakly by some monocytes. CD40 is involved in the process of B cell selection in germinal centers and is vital in T cell-B cell interactions.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted.|
|Precautions||CD40 Antibody (clone LOB7/6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.|
|Cellular Location||Isoform I: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||B-cells and in primary carcinomas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Stamenkovic I.,et al.EMBO J. 8:1403-1410(1989).
Tone M.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:1751-1756(2001).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
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