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SCNN1G / ENaC Gamma Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P51170 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74kDa |
| Dilution | IHC-P (5 µg/ml), WB (1 µg/ml), |
| Gene ID | 6340 |
|---|---|
| Other Names | Amiloride-sensitive sodium channel subunit gamma, Epithelial Na(+) channel subunit gamma, ENaCG, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG, SCNN1G |
| Target/Specificity | synthetic peptide corresponding to C-terminal residues of human SCNN1G(Amiloride-sensitive sodium channel gamma-subunit) |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | SCNN1G / ENaC Gamma Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCNN1G |
|---|---|
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Note=Apical membrane of epithelial cells. |
| Tissue Location | Expressed in kidney (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
References
Voilley N.,et al.Genomics 28:560-565(1995).
McDonald F.J.,et al.Am. J. Physiol. 268:C1157-C1163(1995).
Saxena A.,et al.J. Clin. Endocrinol. Metab. 87:3344-3350(2002).
Thomas C.P.,et al.J. Biol. Chem. 271:26062-26066(1996).
Hansson J.H.,et al.Nat. Genet. 11:76-82(1995).
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