|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Dog|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml),|
|Other Names||Hyaluronidase-1, Hyal-1, 188.8.131.52, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1|
|Target/Specificity||Human HYAL1. This antibody is expected to recognise isoform 1 (NP_009296.1), isoform 2 (NP_695014.1), isoform 3 (NP_695015.1) and isoform 5 (NP_695017.1). Reported variants represent identical protein (NP_009296.1; NP_149349.2; NP_695013.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||HYAL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.|
|Cellular Location||Secreted. Lysosome|
|Tissue Location||Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Wei M.H.,et al.Cancer Res. 56:1487-1492(1996).
Frost G.I.,et al.Biochem. Biophys. Res. Commun. 236:10-15(1997).
Frost G.I.,et al.Oncogene 19:870-877(2000).
Lokeshwar V.B.,et al.J. Biol. Chem. 277:33654-33663(2002).
Forgacs E.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
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