|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Dog|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml),|
|Other Names||Hyaluronidase-1, Hyal-1, 220.127.116.11, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1|
|Target/Specificity||Human HYAL1. This antibody is expected to recognise isoform 1 (NP_009296.1), isoform 2 (NP_695014.1), isoform 3 (NP_695015.1) and isoform 5 (NP_695017.1). Reported variants represent identical protein (NP_009296.1; NP_149349.2; NP_695013.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||HYAL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.|
|Cellular Location||Secreted. Lysosome|
|Tissue Location||Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.|
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May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Wei M.H.,et al.Cancer Res. 56:1487-1492(1996).
Frost G.I.,et al.Biochem. Biophys. Res. Commun. 236:10-15(1997).
Frost G.I.,et al.Oncogene 19:870-877(2000).
Lokeshwar V.B.,et al.J. Biol. Chem. 277:33654-33663(2002).
Forgacs E.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
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