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SCN2B Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SCN2B Antibody (N-Terminus) ALS12354
    Anti-SCN2B antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60939
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (10-20 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 6327
Other Names Sodium channel subunit beta-2, SCN2B
Target/Specificity synthetic peptide corresponding to N-terminal residues of rat Scn2b (Sodium channel beta-2 subunit)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSCN2B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCN2B
Function Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Brain specific.
Research Areas
Citations (0)

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Background

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

References

Eubanks J.,et al.NeuroReport 8:2775-2779(1997).
Bolino A.,et al.Eur. J. Hum. Genet. 6:629-634(1998).
Cruz J.S.,et al.Science 284:711-711(1999).
Isom L.L.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS12354
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