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ITPR1 / IP3 Receptor Type 1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ITPR1 / IP3 Receptor Type 1 Antibody (C-Terminus) ALS12356
    Anti-ITPR1 antibody IHC of human brain, cerebellum.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14643
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 314kDa
Dilution IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 3708
Other Names Inositol 1, 4, 5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1, 4, 5-trisphosphate receptor, Type 1 InsP3 receptor, ITPR1, INSP3R1
Target/Specificity Synthetic peptide corresponding to C-terminal residues of human ITPR1 (Inositol 1,4,5-triphosphate receptor type 1).
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsITPR1 / IP3 Receptor Type 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITPR1
Synonyms INSP3R1
Function Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Endoplasmic reticulum and secretory granules (By similarity). {ECO:0000250|UniProtKB:Q9TU34}
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

References

Yamada N.,et al.Biochem. J. 302:781-790(1994).
Harnick D.J.,et al.J. Biol. Chem. 270:2833-2840(1995).
Marks A.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Nucifora F.C. Jr.,et al.Brain Res. Mol. Brain Res. 32:291-296(1995).
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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Discontinued
Cat# ALS12356
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