ITPR1 / IP3 Receptor Type 1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q14643 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 314kDa |
Dilution | IHC-P (10 µg/ml), WB (1 µg/ml), |
Gene ID | 3708 |
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Other Names | Inositol 1, 4, 5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1, 4, 5-trisphosphate receptor, Type 1 InsP3 receptor, ITPR1, INSP3R1 |
Target/Specificity | Synthetic peptide corresponding to C-terminal residues of human ITPR1 (Inositol 1,4,5-triphosphate receptor type 1). |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | ITPR1 / IP3 Receptor Type 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ITPR1 |
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Synonyms | INSP3R1 |
Function | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Endoplasmic reticulum and secretory granules (By similarity). {ECO:0000250|UniProtKB:Q9TU34} |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
References
Yamada N.,et al.Biochem. J. 302:781-790(1994).
Harnick D.J.,et al.J. Biol. Chem. 270:2833-2840(1995).
Marks A.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Nucifora F.C. Jr.,et al.Brain Res. Mol. Brain Res. 32:291-296(1995).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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