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DNAJA3 / TID1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - DNAJA3 / TID1 Antibody (C-Terminus) ALS12361
    Anti-DNAJA3 / TID1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96EY1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 9093
Other Names DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1
Target/Specificity synthetic peptide corresponding to C-terminal residues of mouse DnaJa3 (DnaJ homolog subfamily A member 3, mitochondrial precursor)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsDNAJA3 / TID1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNAJA3
Synonyms HCA57, TID1
Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Cellular Location Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK
Tissue Location Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes
Volume 50 µl
Research Areas
Citations (0)

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Background

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

References

Schilling B.,et al.Virology 247:74-85(1998).
Sarkar S.,et al.J. Biol. Chem. 276:49034-49042(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Wang Y.,et al.J. Immunol. 169:1102-1109(2002).

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$ 395.00
Cat# ALS12361
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