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DNAJA3 / TID1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96EY1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Dilution | IHC-P (10 µg/ml), WB (1 µg/ml), |
| Gene ID | 9093 |
|---|---|
| Other Names | DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1 |
| Target/Specificity | synthetic peptide corresponding to C-terminal residues of mouse DnaJa3 (DnaJ homolog subfamily A member 3, mitochondrial precursor) |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | DNAJA3 / TID1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJA3 |
|---|---|
| Synonyms | HCA57, TID1 |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Cellular Location | Mitochondrion matrix. Cytoplasm, cytosol. Postsynaptic cell membrane; Peripheral membrane protein. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK |
| Tissue Location | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
References
Schilling B.,et al.Virology 247:74-85(1998).
Sarkar S.,et al.J. Biol. Chem. 276:49034-49042(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Wang Y.,et al.J. Immunol. 169:1102-1109(2002).
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