|Application ||WB, IHC-P|
|Dilution||IHC-P (2.5-5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Plexin domain-containing protein 1, Tumor endothelial marker 3, Tumor endothelial marker 7, PLXDC1, TEM3, TEM7|
|Target/Specificity||A synthetic peptide containing amino acids 411-427 of human TEM7.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||TEM7 Antibody (aa411-427, clone 197C193) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a critical role in endothelial cell capillary morphogenesis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells Isoform 3: Secreted.|
|Tissue Location||Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a critical role in endothelial cell capillary morphogenesis.
St Croix B.,et al.Science 289:1197-1202(2000).
Carson-Walter E.B.,et al.Cancer Res. 61:6649-6655(2001).
Nanda A.,et al.Cancer Res. 64:8507-8511(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lee H.K.,et al.FEBS Lett. 580:2253-2257(2006).
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