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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CCK4 / PTK7 Antibody (C-Terminus)   

CCK4 / PTK7 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - CCK4 / PTK7 Antibody (C-Terminus) ALS12390
    Immunofluorescence of PTK7 in Human Colon cells with PTK7 antibody at 20 ug/ml.
  • IHC - CCK4 / PTK7 Antibody (C-Terminus) ALS12390
    Anti-PTK7 antibody IHC of human kidney.
  • WB - CCK4 / PTK7 Antibody (C-Terminus) ALS12390
    Western blot of PTK7 in (A) human colon, (B) mouse kidney and (C) rat liver tissue lysate with...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13308
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 118kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 5754
Other Names Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, CCK-4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, PTK7, CCK4
Target/Specificity an 18 amino acid peptide from near the carboxy terminus of human PTK7
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCCK4 / PTK7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTK7
Synonyms CCK4
Function Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Cellular Location Membrane; Single-pass type I membrane protein Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells
Tissue Location Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon
Research Areas
Citations (0)

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Background

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

References

Mossie K.,et al.Oncogene 11:2179-2184(1995).
Park S.-K.,et al.J. Biochem. 119:235-239(1996).
Jung J.-W.,et al.Biochim. Biophys. Acta 1579:153-163(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 395.00
Cat# ALS12390
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