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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOCS1 Antibody (N-Terminus)   

SOCS1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SOCS1 Antibody (N-Terminus) ALS12399
    Anti-SOCS1 antibody IHC of human brain, cortex.
  • WB - SOCS1 Antibody (N-Terminus) ALS12399
    Western blot of SOCS1 in Human spleen cell lysate with SOCS1 antibody at (A) 1, (B) 2 and (C) 4...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O15524
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 8651
Other Names Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3, SOCS1, SSI1, TIP3
Target/Specificity 17 amino acid peptide from near the amino terminus of human SOCS1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSOCS1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS1
Synonyms SSI1, TIP3
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Cellular Location Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3
Tissue Location Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
Research Areas
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Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

References

Minamoto S.,et al.Biochem. Biophys. Res. Commun. 237:79-83(1997).
Ohya K.,et al.J. Biol. Chem. 272:27178-27182(1997).
Starr R.,et al.Nature 387:917-921(1997).
Yandava C.N.,et al.Genomics 61:108-111(1999).
Schlueter G.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12399
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