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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UNC93B / UNC93B1 Antibody (N-Terminus)   

UNC93B / UNC93B1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - UNC93B / UNC93B1 Antibody (N-Terminus) ALS12411
    Western blot of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
  • IF - UNC93B / UNC93B1 Antibody (N-Terminus) ALS12411
    Immunofluorescence of Unc93b in Human Heart cells with Unc93b antibody at 20 ug/ml.
  • IHC - UNC93B / UNC93B1 Antibody (N-Terminus) ALS12411
    Anti-UNC93B1 / UNC93B antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9H1C4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 67kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 81622
Other Names Protein unc-93 homolog B1, Unc-93B1, hUNC93B1, UNC93B1, UNC93, UNC93B
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsUNC93B / UNC93B1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC93B1
Synonyms UNC93, UNC93B
Function Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}
Tissue Location Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.
Research Areas
Citations (0)

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Background

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal.

References

Kashuba V.I.,et al.Gene 283:209-217(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kollewe A.,et al.Thesis (2001), University of Hannover, Germany.
Olsen J.V.,et al.Cell 127:635-648(2006).
Casrouge A.,et al.Science 314:308-312(2006).

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$ 395.00
Cat# ALS12411
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