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UNC93B / UNC93B1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9H1C4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.5-1 µg/ml), |
| Gene ID | 81622 |
|---|---|
| Other Names | Protein unc-93 homolog B1, Unc-93B1, hUNC93B1, UNC93B1, UNC93, UNC93B |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | UNC93B / UNC93B1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UNC93B1 (HGNC:13481) |
|---|---|
| Synonyms | UNC93, UNC93B |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome Lysosome. Cytoplasmic vesicle, phagosome Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity) Colocalizes with LAMP5 in large endosomal intracellular vesicles {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595} |
| Tissue Location | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal.
References
Kashuba V.I.,et al.Gene 283:209-217(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kollewe A.,et al.Thesis (2001), University of Hannover, Germany.
Olsen J.V.,et al.Cell 127:635-648(2006).
Casrouge A.,et al.Science 314:308-312(2006).
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