|Application ||WB, IHC-P, IF, ICC, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Kinesin heavy chain isoform 5A, Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC, KIF5A, NKHC1|
|Target/Specificity||a 20 amino acid peptide from near the center of human KIF5|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||Kinesin 5A / KIF5A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.|
|Cellular Location||Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region|
|Tissue Location||Distributed throughout the CNS but is highly enriched in subsets of neurons|
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Provided below are standard protocols that you may find useful for product applications.
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
Niclas J.,et al.Neuron 12:1059-1072(1994).
Nakajima D.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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