|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Plexin domain-containing protein 1, Tumor endothelial marker 3, Tumor endothelial marker 7, PLXDC1, TEM3, TEM7|
|Target/Specificity||a 16 amino acid peptide from near the center of human TEM7|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TEM7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a critical role in endothelial cell capillary morphogenesis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells Isoform 3: Secreted.|
|Tissue Location||Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Plays a critical role in endothelial cell capillary morphogenesis.
St Croix B.,et al.Science 289:1197-1202(2000).
Carson-Walter E.B.,et al.Cancer Res. 61:6649-6655(2001).
Nanda A.,et al.Cancer Res. 64:8507-8511(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lee H.K.,et al.FEBS Lett. 580:2253-2257(2006).
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