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CDNF / ARMETL1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - CDNF / ARMETL1 Antibody (C-Terminus) ALS12431
    Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 ug/ml.
  • IHC - CDNF / ARMETL1 Antibody (C-Terminus) ALS12431
    Anti-CDNF / ARMETL1 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q49AH0
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IHC-P (5 µg/ml), WB (2-4 µg/ml),
Additional Information
Gene ID 441549
Other Names Cerebral dopamine neurotrophic factor, ARMET-like protein 1, Conserved dopamine neurotrophic factor, CDNF, ARMETL1
Target/Specificity a 9 amino acid peptide from near the carboxy terminus of human CDNF
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCDNF / ARMETL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDNF
Synonyms ARMETL1
Function Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Cellular Location Secreted
Tissue Location Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
Research Areas
Citations (0)

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Background

Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lindholm P.,et al.Nature 448:73-77(2007).
Apostolou A.,et al.Exp. Cell Res. 314:2454-2467(2008).
Parkash V.,et al.Protein Eng. Des. Sel. 22:233-241(2009).

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$ 395.00
Cat# ALS12431
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