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IRGM / LRG-47 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • WB - IRGM / LRG-47 Antibody (Internal) ALS12432
    Western blot of IRGM in human brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.
  • IF - IRGM / LRG-47 Antibody (Internal) ALS12432
    Immunofluorescence of IRGM in Human Brain cells with IRGM antibody at 20 ug/ml.
  • IHC - IRGM / LRG-47 Antibody (Internal) ALS12432
    Anti-IRGM antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession A1A4Y4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 20kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 345611
Other Names Immunity-related GTPase family M protein, 3.6.5.-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIRGM / LRG-47 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRGM
Synonyms IFI1, IRGM1, LRG47
Function Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Cellular Location Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Tissue Location Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).

References

Bekpen C.,et al.PLoS Genet. 5:E1000403-E1000403(2009).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bekpen C.,et al.Genome Biol. 6:R92.1-R92.18(2005).
Singh S.B.,et al.Science 313:1438-1441(2006).
Parkes M.,et al.Nat. Genet. 39:830-832(2007).

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$ 395.00
Cat# ALS12432
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