|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Immunity-related GTPase family M protein, 3.6.5.-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IRGM / LRG-47 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IFI1, IRGM1, LRG47|
|Function||Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).|
|Cellular Location||Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.|
|Tissue Location||Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.|
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Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Bekpen C.,et al.PLoS Genet. 5:E1000403-E1000403(2009).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bekpen C.,et al.Genome Biol. 6:R92.1-R92.18(2005).
Singh S.B.,et al.Science 313:1438-1441(2006).
Parkes M.,et al.Nat. Genet. 39:830-832(2007).
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