|Application ||WB, IHC-P, E|
|Reactivity||Human, Rabbit, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Dual specificity protein phosphatase 1, 18.104.22.168, 22.214.171.124, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100, DUSP1, CL100, MKP1, PTPN10, VH1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MKP-1 / DUSP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CL100, MKP1, PTPN10, VH1|
|Function||Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.|
|Tissue Location||Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Keyes S.M.,et al.Nature 359:644-647(1992).
Kwak S.P.,et al.J. Biol. Chem. 269:3596-3604(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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