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MKP-1 / DUSP1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - MKP-1 / DUSP1 Antibody (C-Terminus) ALS12435
    Anti-DUSP1 antibody IHC of human prostate.
    detail
  • WB - MKP-1 / DUSP1 Antibody (C-Terminus) ALS12435
    Antibody (0.3 ug/ml) staining of HeLa lysate (35 ug protein in RIPA buffer).
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P28562
Reactivity Human, Rabbit, Monkey, Pig, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 39kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 1843
Other Names Dual specificity protein phosphatase 1, 3.1.3.16, 3.1.3.48, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100, DUSP1, CL100, MKP1, PTPN10, VH1
Target/Specificity Human DUSP1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMKP-1 / DUSP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP1 (HGNC:3064)
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q91790}.
Tissue Location Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney
Research Areas
Citations (0)
citation

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Background

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

References

Keyes S.M.,et al.Nature 359:644-647(1992).
Kwak S.P.,et al.J. Biol. Chem. 269:3596-3604(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).

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Discontinued
Cat# ALS12435
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