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ATF7 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - ATF7 Antibody (C-Terminus) ALS12436
    Anti-ATF7 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P17544
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 53kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 11016
Other Names Cyclic AMP-dependent transcription factor ATF-7, cAMP-dependent transcription factor ATF-7, Activating transcription factor 7, Transcription factor ATF-A, ATF7, ATFA
Target/Specificity Human ATF7. This antibody is expected to recognise all three reported isoforms (NP_001123531.1, NP_006847.1 and NP_001123532.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsATF7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATF7
Synonyms ATFA
Function Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:17264123}. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region The sumoylated form locates to the nuclear periphery
Tissue Location Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Citations (0)

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Background

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

References

Gaire M.,et al.Nucleic Acids Res. 18:3467-3473(1990).
Chatton B.,et al.Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases.
Pescini R.,et al.J. Biol. Chem. 269:1159-1165(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS12436
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