|Application ||WB, IHC-P, E|
|Reactivity||Human, Rabbit, Monkey|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.2-1 µg/ml)|
|Other Names||Annexin A11, 56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50, ANXA11, ANX11|
|Target/Specificity||Human ANXA11 / Annexin A11. NP_001148.1; NP_665875.1 and NP_665876.1 are varients that encode the same protein.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ANXA11 / Annexin XI Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.|
|Cellular Location||Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity) Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent.|
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Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
Misaki Y.,et al.J. Biol. Chem. 269:4240-4246(1994).
Bances P.,et al.Genomics 69:95-103(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Satoh H.,et al.Biochem. Biophys. Res. Commun. 291:1166-1172(2002).
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