|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, 3.4.24.-, Meltrin-alpha, ADAM12, MLTN|
|Target/Specificity||Human ADAM12. This antibody is expected to recognise both the longer membrane-bound form of human ADAM12 (NP_003465.3) and the shorter soluble ADAM12 splice isoform (NP_067673.2). This antibody does not cross-react with other ADAMS.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ADAM12 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas|
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Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Gilpin B.J.,et al.J. Biol. Chem. 273:157-166(1998).
Gilpin B.J.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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