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KLKB1 / Plasma Kallikrein Antibody

Sheep Polyclonal Antibody

     
  • IHC - KLKB1 / Plasma Kallikrein Antibody ALS12464
    Anti-KLKB1 antibody IHC of human small intestine, vessels.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IE
Primary Accession P03952
Reactivity Human
Host Sheep
Clonality Polyclonal
Calculated MW 71kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 3818
Other Names Plasma kallikrein, 3.4.21.34, Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain, KLKB1, KLK3
Target/Specificity Specific for PK as demonstrated by immunoelectrophoresis and ELISA.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsKLKB1 / Plasma Kallikrein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLKB1
Synonyms KLK3
Function Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin- angiotensin system by converting prorenin into renin.
Cellular Location Secreted.
Tissue Location Found in plasma (at protein level).
Research Areas
Citations (0)
citation

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Background

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

References

Chung D.W.,et al.Biochemistry 25:2410-2417(1986).
Yu H.,et al.Genomics 69:225-234(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS12464
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