KLKB1 / Plasma Kallikrein Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E, IE |
---|---|
Primary Accession | P03952 |
Reactivity | Human |
Host | Sheep |
Clonality | Polyclonal |
Calculated MW | 71kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 3818 |
---|---|
Other Names | Plasma kallikrein, 3.4.21.34, Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain, KLKB1, KLK3 |
Target/Specificity | Specific for PK as demonstrated by immunoelectrophoresis and ELISA. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | KLKB1 / Plasma Kallikrein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLKB1 |
---|---|
Synonyms | KLK3 |
Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin- angiotensin system by converting prorenin into renin. |
Cellular Location | Secreted. |
Tissue Location | Found in plasma (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
References
Chung D.W.,et al.Biochemistry 25:2410-2417(1986).
Yu H.,et al.Genomics 69:225-234(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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