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SLC2A1 / GLUT-1 Antibody (C-Terminus, clone SPM498)

Mouse Monoclonal Antibody

     
  • IHC - SLC2A1 / GLUT-1 Antibody (C-Terminus, clone SPM498) ALS12469
    Anti-SLC2A1 / GLUT1 antibody IHC of human placenta.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P11166
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Clone Names SPM498
Calculated MW 54kDa
Dilution IHC-P (15 µg/ml)
Additional Information
Gene ID 6513
Other Names Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, GLUT-1, HepG2 glucose transporter, SLC2A1, GLUT1
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSLC2A1 / GLUT-1 Antibody (C-Terminus, clone SPM498) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC2A1 (HGNC:11005)
Function Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Melanosome. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065)
Tissue Location Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues
Volume Array
Research Areas
Citations (0)
citation

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Background

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.

References

Mueckler M.,et al.Science 229:941-945(1985).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Fukumoto H.,et al.Diabetes 37:657-661(1988).
Yu W.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS12469
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