|Application ||WB, IHC-P, IP, Flo, Func|
|Calculated MW||40322 Da|
|Dilution||Func, IHC-P (10 µg/ml),|
|Other Names||Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43|
|Target/Specificity||Recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 kD type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocyte ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||SPN / CD43 Antibody (clone MEM-59) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas|
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