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PAG1 Antibody (aa97-432, clone MEM-255)

Mouse Monoclonal Antibody

     
  • IHC - PAG1 Antibody (aa97-432, clone MEM-255) ALS12481
    Anti-PAG1 / PAG antibody IHC of human tonsil.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession Q9NWQ8
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names MEM-255
Calculated MW 47kDa
Dilution Flo (2 µg/ml), IHC-P (10 µg/ml),
Additional Information
Gene ID 55824
Other Names Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1, CBP, PAG
Target/Specificity Recognizes an epitope (aa 235-280) of Csk-binding protein (Cbp) located in the cytoplasmic domain, also known as protein associated with glycosphingolipid-enriched microdomains (PAG)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsPAG1 Antibody (aa97-432, clone MEM-255) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAG1
Synonyms CBP, PAG
Function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Cellular Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts
Tissue Location Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
Research Areas
Citations (0)
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Background

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

References

Brdicka T.,et al.J. Exp. Med. 191:1591-1604(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brdickova N.,et al.FEBS Lett. 507:133-136(2001).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).

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Discontinued
Cat# ALS12481
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