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ERCC3 / XPB Antibody (aa242-261, clone 3G4)

Mouse Monoclonal Antibody

     
  • IHC - ERCC3 / XPB Antibody (aa242-261, clone 3G4) ALS12491
    Anti-ERCC3 / XPB antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession P19447
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G4
Calculated MW 89kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 2071
Other Names TFIIH basal transcription factor complex helicase XPB subunit, 3.6.4.12, Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH 89 kDa subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein, ERCC3, XPB, XPBC
Target/Specificity Recognizes an epitope located between aa242-261 of ERCC-3 (largest subunit of TFIIH).
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsERCC3 / XPB Antibody (aa242-261, clone 3G4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERCC3
Synonyms XPB, XPBC
Function ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.

References

Weeda G.,et al.Mol. Cell. Biol. 10:2570-2581(1990).
Weeda G.,et al.Cell 62:777-791(1990).
Weeda G.,et al.Nucleic Acids Res. 19:6301-6308(1991).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12491
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