|Application ||WB, IHC-P, E, IP|
|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||TFIIH basal transcription factor complex helicase XPB subunit, 220.127.116.11, Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH 89 kDa subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein, ERCC3, XPB, XPBC|
|Target/Specificity||Recognizes an epitope located between aa242-261 of ERCC-3 (largest subunit of TFIIH).|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ERCC3 / XPB Antibody (aa242-261, clone 3G4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.|
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Provided below are standard protocols that you may find useful for product applications.
ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
Weeda G.,et al.Mol. Cell. Biol. 10:2570-2581(1990).
Weeda G.,et al.Cell 62:777-791(1990).
Weeda G.,et al.Nucleic Acids Res. 19:6301-6308(1991).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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