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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RNF125 Antibody   

RNF125 Antibody

Rabbit Polyclonal Antibody

     
  • WB - RNF125 Antibody ALS12493
    Western blot of TRAC-1 in spleen lysate.
  • IHC - RNF125 Antibody ALS12493
    Anti-RNF125 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q96EQ8
Reactivity Human, Mouse, Rat, Monkey, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Dilution IHC-P (1:100), WB (1:500-1:1000),
Additional Information
Gene ID 54941
Other Names E3 ubiquitin-protein ligase RNF125, 6.3.2.-, RING finger protein 125, T-cell RING activation protein 1, TRAC-1, RNF125
Target/Specificity A portion of amino acid 100-150 of human TRAC-1
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsRNF125 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF125
Function E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.
Cellular Location Golgi apparatus membrane; Lipid-anchor. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.
Tissue Location Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chu P.,et al.J. Biol. 2:21.1-21.16(2003).
Zhao H.,et al.J. Immunol. 174:5288-5297(2005).

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$ 395.00
Cat# ALS12493
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