|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Horse, Bovine, Dog|
|Dilution||IHC-P (1:100), WB (1:500-1:1000),|
|Other Names||E3 ubiquitin-protein ligase RNF125, 6.3.2.-, RING finger protein 125, T-cell RING activation protein 1, TRAC-1, RNF125|
|Target/Specificity||A portion of amino acid 100-150 of human TRAC-1|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||RNF125 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Golgi apparatus membrane; Lipid-anchor. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.|
|Tissue Location||Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chu P.,et al.J. Biol. 2:21.1-21.16(2003).
Zhao H.,et al.J. Immunol. 174:5288-5297(2005).
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