|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Horse, Bovine, Dog|
|Dilution||IHC-P (1:100), WB (1:500-1:1000),|
|Other Names||E3 ubiquitin-protein ligase RNF125, 6.3.2.-, RING finger protein 125, T-cell RING activation protein 1, TRAC-1, RNF125|
|Target/Specificity||A portion of amino acid 100-150 of human TRAC-1|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||RNF125 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.|
|Tissue Location||Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chu P.,et al.J. Biol. 2:21.1-21.16(2003).
Zhao H.,et al.J. Immunol. 174:5288-5297(2005).
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