|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml)|
|Other Names||Leucine-rich repeat-containing protein 7, Densin-180, Densin, Protein LAP1, LRRC7, KIAA1365, LAP1|
|Target/Specificity||synthetic peptide corresponding to N-terminal residues of human LRRC7(Leucine-rich repeat-containing protein 7)|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||LAP1 / LRRC7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.|
|Cellular Location||Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density|
|Tissue Location||Brain-specific. Isoform 3 is ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Izawa I.,et al.J. Biol. Chem. 277:5345-5350(2002).
Wang L.,et al.Int. J. Mol. Med. 11:257-260(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nagase T.,et al.DNA Res. 7:65-73(2000).
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