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LAP1 / LRRC7 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - LAP1 / LRRC7 Antibody (N-Terminus) ALS12494
    Anti-LRRC7 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96NW7
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 173kDa
Dilution ELISA (1 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 57554
Other Names Leucine-rich repeat-containing protein 7, Densin-180, Densin, Protein LAP1, LRRC7, KIAA1365, LAP1
Target/Specificity synthetic peptide corresponding to N-terminal residues of human LRRC7(Leucine-rich repeat-containing protein 7)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsLAP1 / LRRC7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRRC7
Synonyms KIAA1365, LAP1
Function Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Cellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Tissue Location Brain-specific. Isoform 3 is ubiquitously expressed.
Research Areas
Citations (0)

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Background

Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

References

Izawa I.,et al.J. Biol. Chem. 277:5345-5350(2002).
Wang L.,et al.Int. J. Mol. Med. 11:257-260(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nagase T.,et al.DNA Res. 7:65-73(2000).

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$ 395.00
Cat# ALS12494
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