|Application ||WB, IHC-P, IHC-Fr|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Myelin proteolipid protein, PLP, Lipophilin, PLP1, PLP|
|Target/Specificity||Recognizes myelin proteolipid protein (PLP) in many mammalian species. This Recognizes DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted.|
|Precautions||PLP1 / Myelin PLP Antibody (C-Terminus, clone plpc1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Myelin membrane. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.|
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Provided below are standard protocols that you may find useful for product applications.
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Diehl H.-J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:9807-9811(1986).
Simons R.,et al.Biochem. Biophys. Res. Commun. 146:666-671(1987).
Hudson L.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:8128-8131(1989).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
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