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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RCC1 Antibody   

RCC1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - RCC1 Antibody ALS12520
    Anti-RCC1 antibody IHC staining of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession P18754
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Dilution IHC-P (1:100), WB (1:500),
Additional Information
Gene ID 1104
Other Names Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, CHC1
Target/Specificity Reacts with human & Xenopus RanGEF
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsRCC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCC1
Synonyms CHC1
Function Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.
Cellular Location Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis
Volume 50 µl
Research Areas
Citations (0)

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Background

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.

References

Ohtsubo M.,et al.Genes Dev. 1:585-593(1987).
Furuno N.,et al.Genomics 11:459-461(1991).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Miyabashira J.,et al.J. Cell Sci. 107:2203-2208(1994).
Bischoff F.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8617-8621(1990).

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$ 395.00
Cat# ALS12520
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