|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (1:100), WB (1:500-1:1000),|
|Other Names||Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD|
|Target/Specificity||Reacts with human & Xenopus RanGAP|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RANGAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.|
|Cellular Location||Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase Mitotic location also requires sumoylation|
|Tissue Location||Highly expressed in brain, thymus and testis.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Bischoff F.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1749-1753(1995).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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