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PP2Ac / PPP2CA Antibody (clone P6C7)

Mouse Monoclonal Antibody

     
  • WB - PP2Ac / PPP2CA Antibody (clone P6C7) ALS12538
    Mouse liver cytosol extract was resolved by electrophoresis, transferred to PVDF membrane and...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession P67775
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names P6C7
Calculated MW 36kDa
Dilution IHC-P (15 µg/ml), WB (1:250-1:1000),
Additional Information
Gene ID 5515
Other Names Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, 3.1.3.16, Replication protein C, RP-C, PPP2CA
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsPP2Ac / PPP2CA Antibody (clone P6C7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2CA
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity).
Research Areas
Citations (0)

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Background

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

References

Stone S.R.,et al.Nucleic Acids Res. 16:11365-11365(1988).
Arino J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4252-4256(1988).
Khew-Goodall Y.,et al.Biochemistry 30:89-97(1991).
Scheidtmann K.H.,et al.Mol. Cell. Biol. 11:1996-2003(1991).
Favre B.,et al.J. Biol. Chem. 269:16311-16317(1994).

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$ 395.00
Cat# ALS12538
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