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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   MIF Antibody (clone 4E4)   

MIF Antibody (clone 4E4)

Mouse Monoclonal Antibody

     
  • IHC - MIF Antibody (clone 4E4) ALS12541
    Anti-MIF antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P14174
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E4
Calculated MW 12kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:2000),
Additional Information
Gene ID 4282
Other Names Macrophage migration inhibitory factor, MIF, 5.3.2.1, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, 5.3.3.12, Phenylpyruvate tautomerase, MIF, GLIF, MMIF
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsMIF Antibody (clone 4E4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MIF
Synonyms GLIF, MMIF
Function Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Cellular Location Secreted. Cytoplasm Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Research Areas
Citations (0)

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Background

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

References

Weiser W.Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7522-7526(1989).
Mikayama T.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10056-10060(1993).
Bernhagen J.,et al.Biochemistry 33:14144-14155(1994).
Paralkar V.,et al.Genomics 19:48-51(1994).
Shan Z.X.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12541
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