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PSPH Antibody (aa1-225, clone 3G12)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P78330 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3G12 |
| Calculated MW | 25kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:1000-1:2000), |
| Gene ID | 5723 |
|---|---|
| Other Names | Phosphoserine phosphatase, PSP, PSPase, 3.1.3.3, L-3-phosphoserine phosphatase, O-phosphoserine phosphohydrolase, PSPH |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | PSPH Antibody (aa1-225, clone 3G12) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PSPH (HGNC:9577) |
|---|---|
| Function | Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L- serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166). L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469). May also act on O-phospho-D-serine (Probable). |
| Cellular Location | Cytoplasm, cytosol. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
References
Collet J.-F.,et al.FEBS Lett. 408:281-284(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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