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VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5)

Mouse Monoclonal Antibody

     
  • IHC - VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) ALS12552
    Anti-VAMP2 antibody IHC of human adrenal.
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  • IHC - VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) ALS12552
    Anti-VAMP2 antibody IHC of human brain, cerebellum.
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  • IHC - VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) ALS12552
    Anti-VAMP2 antibody IHC of human testis.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P63027
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3E5
Calculated MW 13kDa
Dilution IHC-P (10 µg/ml), WB (1:2000-1:3000),
Additional Information
Gene ID 6844
Other Names Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2, VAMP2, SYB2
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsVAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAMP2 (HGNC:12643)
Synonyms SYB2
Function Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651)
Tissue Location Nervous system and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

References

Archer B.T. III,et al.J. Biol. Chem. 265:17267-17273(1990).
Nabokina S.M.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Taruscio D.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS12552
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