VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P63027 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3E5 |
Calculated MW | 13kDa |
Dilution | IHC-P (10 µg/ml), WB (1:2000-1:3000), |
Gene ID | 6844 |
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Other Names | Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2, VAMP2, SYB2 |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | VAMP2 / VAMP-2 Antibody (aa1-89, clone 3E5) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | VAMP2 (HGNC:12643) |
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Synonyms | SYB2 |
Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651) |
Tissue Location | Nervous system and skeletal muscle. |
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Background
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
References
Archer B.T. III,et al.J. Biol. Chem. 265:17267-17273(1990).
Nabokina S.M.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Taruscio D.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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