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CD45 Antibody (aa1029-1249, clone 3G4)

Mouse Monoclonal Antibody

     
  • IHC - CD45 Antibody (aa1029-1249, clone 3G4) ALS12557
    Anti-CD45 antibody IHC of human thymus.
  • IHC - CD45 Antibody (aa1029-1249, clone 3G4) ALS12557
    Anti-CD45 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P08575
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G4
Calculated MW 147kDa
Dilution IHC-P (10 µg/ml), WB (1:1000-1:3000),
Additional Information
Gene ID 5788
Other Names Receptor-type tyrosine-protein phosphatase C, 3.1.3.48, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsCD45 Antibody (aa1029-1249, clone 3G4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRC
Synonyms CD45
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Research Areas
Citations (0)

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Background

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

References

Streuli M.,et al.J. Exp. Med. 166:1548-1566(1987).
Ralph S.J.,et al.EMBO J. 6:1251-1257(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tsai A.Y.M.,et al.Mol. Cell. Biol. 9:4550-4555(1989).
Hall L.R.,et al.J. Immunol. 141:2781-2787(1988).

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$ 395.00
Cat# ALS12557
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