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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PDCD4 Antibody (aa1-469, clone K4C1)   

PDCD4 Antibody (aa1-469, clone K4C1)

Mouse Monoclonal Antibody

     
  • IHC - PDCD4 Antibody (aa1-469, clone K4C1) ALS12564
    Anti-PDCD4 antibody IHC of human breast.
  • IHC - PDCD4 Antibody (aa1-469, clone K4C1) ALS12564
    Anti-PDCD4 antibody IHC of human spleen.
  • WB - PDCD4 Antibody (aa1-469, clone K4C1) ALS12564
    Cell lysates of HepG2(40 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q53EL6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names K4C1
Calculated MW 52kDa
Dilution IHC-P (5 µg/ml), WB (1:1000-1:3000),
Additional Information
Gene ID 27250
Other Names Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, PDCD4, H731
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsPDCD4 Antibody (aa1-469, clone K4C1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCD4
Synonyms H731
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133).
Tissue Location Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma
Research Areas
Citations (0)

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Background

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

References

Matsuhashi S.,et al.Res. Commun. Biochem. Cell Mol. Biol. 1:109-120(1997).
Azzoni L.,et al.J. Immunol. 161:3493-3500(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).

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$ 395.00
Cat# ALS12564
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