ACOT11 / THEA Antibody (aa19-250, clone J4B2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q8WXI4 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | J4B2 |
Calculated MW | 68kDa |
Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
Gene ID | 26027 |
---|---|
Other Names | Acyl-coenzyme A thioesterase 11, Acyl-CoA thioesterase 11, 3.1.2.-, Acyl-CoA thioester hydrolase 11, Adipose-associated thioesterase, Brown fat-inducible thioesterase, BFIT, ACOT11, BFIT, KIAA0707, THEA |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | ACOT11 / THEA Antibody (aa19-250, clone J4B2) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACOT11 |
---|---|
Synonyms | BFIT, KIAA0707, THEA |
Function | Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. |
Cellular Location | Mitochondrion matrix. Cytoplasm |
Tissue Location | Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue |
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Background
Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.
References
Adams S.H.,et al.Biochem. J. 360:135-142(2001).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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