|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (2.5-5 µg/ml),|
|Other Names||Vitamin D3 receptor, VDR, 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1|
|Target/Specificity||Recognizes human VDR.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Vitamin D Receptor / VDR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.|
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Provided below are standard protocols that you may find useful for product applications.
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Baker A.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H.,et al.Biochim. Biophys. Acta 1132:103-108(1992).
Rae J.L.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Miyamoto K.,et al.Mol. Endocrinol. 11:1165-1179(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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